Table 1.
Definitions.
| Protein and terms | Definition and attributes |
|---|---|
| AMPK | AMP-activated protein kinase is a serine/threonine protein kinase complex that plays an important role in the regulation of energy homeostasis |
| ASX | Additional sex comb belongs to Drosophila genes termed as enhancers of Trithorax and Polycomb (ETP) |
| ASXL1, -2, -3 | Additional sex comb-like proteins are vertebrate orthologues of ASX |
| ATF3 | Activating transcription factor 3 is a stress-responsive member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) family of transcription factors |
| BAP1 | Initially identified as a breast cancer type 1 susceptibility protein (BRCA1)-associated protein and was implicated in the regulation of BRCA1 function |
| BAP1 cancer syndrome | A hereditary cancer syndrome associated with an increased risk for uveal melanoma, malignant mesothelioma, and other cancers |
| CHOP | C/EBP homologous protein is a stress-responsive member of the CCAAT/enhancer-binding (C/EBP) family of DNA-binding transcription factors |
| FOXK1, -2 | Member of the K family of forkhead transcription factors |
| GNAQ,GNA11 | Members of the guanine nucleotide-binding proteins (G proteins) family |
| H2Aub | Histone H2AK119ub in vertebrates (H2AK118 in Drosophila) is a histone modification mediated by the Polycomb Repressive Complex 1 (PRC1) |
| HAT1 | A type B histone acetyltransferase (HAT) involved in chromatin assembly and other processes |
| HBM | HCF-1 binding motif, a four amino acid motif found in BAP1 and other chromatin-associated proteins and is used for interaction with HCF-1 |
| HCF-1 | Host cell factor 1 (HCFC1, HCF-1) is an abundant chromatin-associated protein with Kelch repeats, proteolytic cleavage sites, and fibronectin-like motifs |
| KDM1B | Lysine demethylase (flavin-containing domain 1, AOF1) is a histone H3 lysine 4 (H3K4)-specific demethylase |
| KDM6A (UTX) | Lysine demethylase 6A is a JmjC domain-containing histone H3 lysine 27 (H3K27)-specific demethylase |
| KMT2C (MLL3) | Lysine methyltransferase 2C is a histone H3K4 methyltransferase |
| KLF5 | Krüppel-like factor 5 is a member of the Krüppel-like factor subfamily of zinc-finger transcription factors |
| MPeM | Malignant peritoneal mesothelioma a rare cancer of the peritoneal lining of the abdomen |
| MPM | Malignant pleural mesothelioma is a cancer of the pleural membrane that surrounds the lungs |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase |
| PR-DUB | Drosophila Polycomb group repressive DUB complex formed by Calypso (ortholog of BAP1) and ASX |
| UBE2O | Ubiquitin-conjugating enzyme E2O is an E2 ubiquitin-conjugation enzyme that also acts as an E3 ubiquitin ligase |
| UCH family | A four-member DUB family characterized by a highly conserved catalytic domain harboring a cysteine–histidine–aspartate triad that ensures enzymatic catalysis (UCHL1, UCHL3, UCHL5(UCH37), BAP1) |
| UM | Uveal melanoma is a primary intraocular melanocyte-derived tumor that involves the iris, the ciliary body, or the choroid |
| YY1 | Yin Yang 1 (also known as δ, NF-E1, UCRBP, and CF1) is a zinc-finger member of the GLI-Krüppel class transcription factors |