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. 2021 Feb 1;12(2):139. doi: 10.1038/s41419-021-03431-2

Fig. 2. GSDME deletion attenuated cisplatin-induced renal function loss and pathological injury.

Fig. 2

WT, HET, and KO mice (12 weeks) were subjected to 25 mg/kg of cisplatin or the same volume of saline (Saline group, n = 5; Cisplatin group, n = 7). a Expression of GSDME in mouse kidneys by immunoblotting (n = 2). b, c Serum Cr, BUN, and Cystatin C levels of mice. d PAS staining and the associated renal tubular injury score analysis (scale bar = 20 μm). e Renal protein level of NGAL in kidney tissues, as detected by immunohistochemistry (scale bar = 20 μm). f Immunoblotting of NGAL and KIM-1 in kidney tissues. *P < 0.05, **P < 0.01, and ***P < 0.001.