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. 2021 Feb 1;12(2):139. doi: 10.1038/s41419-021-03431-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Human TECs (HK-2) were transfected with FL-GSDME or the corresponding control and subsequently treated with cisplatin (10 μg/mL) for 24 h. a Protein expression of HA-FL-GSDME with HA and GSDME antibody. b Transcriptional levels of NGAL and KIM-1 (n = 3). c Representative bright-field microscopic images of cells. Red arrowheads indicate large bubbles from the plasma membrane (scale bar = 50 μm). d LDH release in cells overexpressing FL-GSDME (n = 6). e Effect of FL-GSDME on the cell viability (n = 6). f, g IL-1β and IL-6 released in culture medium of cells. h Effect of FL-GSDME on p-p65 protein levels (n = 3). *P < 0.05, **P < 0.01, and ***P < 0.001.