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. 2021 Jan 22;13:608001. doi: 10.3389/fnmol.2020.608001

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Copyright © 2021 Cattaneo, Verlengia, Marino, Simonato and Bettegazzi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neuropeptide Y processing and its potential role in the epileptic hippocampal network. (A) Schematic representation of NPY intracellular processing and extracellular metabolism. (B) Illustration of hippocampal formation rearrangements after an epileptic insult. Red dots represent synapses newly formed by the mossy fiber sprouting in the inner molecular layer that contain NPY and pre-synaptic Y2 receptors. DG, dentate gyrus; CA3/CA1, Cornu Ammonis; OML, outer molecular layer; IML, inner molecular layer; GCL, granule cell layer.