Table 1.
Comparison of different gene therapy strategies designed to modulate the NPY system, based on the use of recombinant adeno-associated vectors.
| First author (year) | Species | Model of epilepsy | Vector | Time of vector delivery | Transgene |
|---|---|---|---|---|---|
| Richichi et al. (2004) | WT rats | Intrahippocampal and intracerebroventricular kainic acid; Kindling |
rAAV2_NSE-NPY; rAAV1/2-NSE-NPY |
Before seizure onset | Human pre-pro-NPY |
| Lin et al. (2006) | WT mice; Y1 -/- and Y2 -/- mice |
Systemic kainic acid | rAAV1/2_NSE-NPY | Before seizure onset | Human NPY cDNA |
| Foti et al. (2007) | WT rats | Intraperitoneal kainic acid | rAAV2_CBA-NPY; rAAV2_CBA-NPY13-36 |
Before seizure onset | Full length and NPY13-36 (Species not specified) |
| Sørensen et al. (2008) | WT rats | None | rAAV1/2_NSE-NPY | N/A | Human pre-pro-NPY |
| Noè et al. (2008) | WT rats | Electrically induced status epilepticus | rAAV1/2_CBA-NPY | After seizure onset | Human pre-pro-NPY |
| Sørensen et al. (2009) | WT rats | Kindling | rAAV1/2_NSE-NPY | Before seizure onset | Human pre-pro-NPY |
| Noè et al. (2010) | WT rats | Intrahippocampal kainic acid | rAAV1_CBA-NPY; rAAV1/2_CBA-NPY |
After seizure onset | Human pre-pro-NPY |
| Woldbye et al. (2010) | WT rats | Kindling; Subcutaneous kainic acid |
rAAV1/2_NSE-NPY; rAAV1/2_NSE-Y2 |
After seizure onset | Human pre-pro-NPY Full length mouse Y2 receptor |
| Gøtzsche et al. (2012) | WT rats | Subcutanous kainic acid | rAAV1/2_NSE-Y5; rAAV1/2_NSE-NPY |
Before seizure onset | Human pre-pro-NPY Full length mouse Y5 receptor |
| Olesen et al. (2012b) | WT mice | Subcutaneous kainic acid | rAAV1/2_NSE-Y1 | After seizure onset | Full length mouse Y1 receptor |
| Olesen et al. (2012a) | WT mice | Subcutaneous kainic acid | rAAV1/2_NSE-Y5 | After seizure onset | Full length mouse Y5 receptor |
| Dong et al. (2013) | WT rats | Intrahippocampal kainic acid | rAAV1/2_CMV-NPY | Before seizure onset | Full length NPY (species not specified) |
| Zhang et al. (2013) | WT rats | Intracerebroventricular kainic acid | rAAV1/2_NPY (unknown promoter) | Before seizure onset | Not specified |
| Nikitidou Ledri et al. (2016) | WT rats | Intrahippocampal kainic acid | rAAV1/2_NSE-NPY; rAAV1/2_NSE-Y2 |
Before seizure onset | Human pre-pro-NPY Full length mouse Y2 receptor |
| Powell et al. (2018) | GAERS (Genetic Absence Epilepsy Rats) | None | rAAV1/2_NSE-NPY | N/A | Human pre-pro-NPY |
| Melin et al. (2019) | WT rats | Intrahippocampal kainic acid | rAAV1_CAG-NPY/Y2 | Before seizure onset | Human pre-pro-NPY Human Y2 receptor |