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. 2021 Jan 22;10:598026. doi: 10.3389/fonc.2020.598026

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Copyright © 2021 Magen, Shufaro, Daykan, Oron, Tararashkina, Levenberg, Anuka, Ben-Haroush, Fisch and Abir

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative microscopy images of thawed-ungrafted controls and grafts. (A) Section of grafted ovarian tissue from a 10-year-old girl, embedded in a fibrin clot combined with host treatment with simvastatin (group E). Note the clear bordered fibrin capsule surrounding the graft. Hematoxlin and eosin, original magnification X100. (B) Section of thawed-ungrafted ovarian tissue (group A) from a 13-year-old girl. Note the primary follicle (black arrow) and the primordial atretic follicle (white arrow). Hematoxylin and eosin, original magnification X400. (C) Section of grafted ovarian tissue from the same patient as in panel 3A, embedded in a fibrin clot combined with host treatment with simvastatin (group E). Note the primary follicle (black arrow) and primordial follicle (white arrow). Hematoxlin and eosin, original magnification X400. (D) Section of thawed-ungrafted ovarian tissue (group A) from a 23-year-old woman. Note the red-brown PECAM staining surrounding the blood vessels in the center of the graft. Original magnification X400. (E) Section of grafted ovarian tissue from the same patient as in panel 3D with host treatment with simvastatin (group C). Note the red-brown PECAM staining in the periphery of the graft. Original magnification X400. (F) Section of untreated-grafted ovarian tissue (group B) from a 13-year-old girl. Note the brown TUNEL staining surrounding the blood vessels indicative of apoptosis. Note the negative control on the upper right-hand side showing blue staining and lacking brown staining. Original magnification X400. (G) Section of grafted ovarian tissue from the same patient as in panel 3A and 3C, embedded in a fibrin clot combined with host treatment with simvastatin (group E). Note the follicle (black arrow) containing red-brown-stained granulosa cells (positive for Ki67) indicating follicular proliferation. Original magnification X400.