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. 2021 Jan 22;11:627666. doi: 10.3389/fgene.2020.627666

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Copyright © 2021 Yang, Liang, Pallas, Hoenerhoff, Ren, Han, Zhang, Chen, Jin, Sun and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Design and validation of guide RNAs. (A) illustration of gRNA design. Blue box: sgRNA sequence. Bold letters within the blue box: PAM sequence. Yellow box: the F508 or the ΔF508 sequence. (B) In vitro validation results of sg01 and sg02.