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. 2021 Jan 22;12:585873. doi: 10.3389/fnagi.2020.585873

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Copyright © 2021 Habif, Do Carmo, Báez, Colettis, Cercato, Salas, Acutain, Sister, Berkowicz, Canal, González Garello, Cuello and Jerusalinsky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Long-term memory (LTM) of inhibitory avoidance (IA) in 3-, 4-, and 6-month-old McGill-R-Thy1-APP Tg+/– rats. (A) IA task: Training and Test Latencies. Tg+/– (dark gray bars) and wt littermates (white bars) were trained in a step through IA to a mild foot-shock (0.5 mA) and tested 24 h later. Latencies to enter the dark compartment (from a lighted one) were recorded. The bar diagram represents median of latencies and interquartile ranges (25;75). Test latencies (Te, stripped bars) to enter the dark compartment were significantly higher than training latencies (Tr, plain bars) for 3, 4, and 6-month-old wt rats. However, only 3-month-old Tg+/– rats showed a significant difference between Te and Tr latencies. Neither 4- nor 6-month-old Tg rats showed differences between Te and Tr latencies. Significant differences were assessed by Wilcoxon matched pairs signed rank test; *P < 0.05, **P < 0.01, ***P < 0.001. (B). IA task: (Te – Tr) Latencies Difference. Bar diagram represents median of (Te-Tr) difference of latencies, with interquartile ranges (25;75) for the same groups as in A. Differences were significantly lower in Tg+/– (stripped bars) than in wt (plain bars) rats of 4 (light gray) and 6 (dark gray) months, whilst there were no statistically significant differences among the difference of latencies by genotype in 3-month-old rats (Unmatched Kruskal-Wallis test with Dunn's multiple comparisons. *P < 0.05, ***P < 0.001). Tt-Tr latency difference of 3-month-old Tg+/– rats was significantly different form zero, while latency differences for 4- and 6-month-old Tg+/– rats were not different from zero. Unmatched Kruskal-Wallis test with Dunn's multiple comparisons. *P < 0.05) (3 mo: N_wt = 8, N_Tg+/− = 7; 4 mo: N_wt = 7, N_Tg+/− = 11; 6 mo: N_wt = 11, N_Tg+/− = 13). (C) Tail-Flick latency. Tail withdrawal latency from a hot (51 ± 1°C) water bath is represented in the scatter plot. No significant differences were observed between any selected pair of animals (Tg or wt) of a given age (Unpaired Mann-Whitney test).