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. 2021 Jan 22;12:585873. doi: 10.3389/fnagi.2020.585873

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Copyright © 2021 Habif, Do Carmo, Báez, Colettis, Cercato, Salas, Acutain, Sister, Berkowicz, Canal, González Garello, Cuello and Jerusalinsky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Social approach comparative behavior of McGill-R-Thy1-APP Homozygous Tg+/+ and Heterozygous Tg+/– rats. (A) Schematic representation of the task steps. 4-month-old Tg+/+, Tg+/– rats and their wt littermates were tested in an adapted version of the three-chambered task. Step 1: OF habituation. Step 2: Control for location/cages (lack of) preference. Erat explores the OF with A and B empty cages. Step 3: “Sociability” assessment. Erat explores the OF with a Nrat (novel rat, same sex, and age) in one cage, and an object (similar size and color than Nrat) in the other cage. (B) “Sociability”: Total exploration time of targets (Nrat or Object) during the 5 min session (Step 3 in A). Bar diagram represents the time (mean ± SEM) an Erat spent exploring an unknown Nrat, or an unknown object (O). Tg+/– animals (dark gray bars, N_Tg+/− = 13), Tg+/+ animals (light gray bars, N_Tg+/+ = 6), wt littermates (white bars, N_wt = 6). Object (O): stripped bars; Novel animal (Nrat): plain bars. Tg+/– and wt rats spent more time exploring a Nrat than the object; while Tg+/+ rats spent significantly more time exploring the object (***P < 0.001, **P < 0.01, Paired t-test). (C) Sociability Preference Index (PI = Nrat–O/Nrat+O) was calculated using the data shown in B. During the social task, wt (white bars) and Tg+/– (dark gray bars) Erats spent more time exploring the Nrat than the object (PI_N−0 > 0; plain bars), while Tg+/+ Erats spent more time exploring the object than the Nrat (PI_N−0 < 0; stripped bars). ****P < 0.0001, One-way ANOVA, Dunnett post- hoc test.