Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 22;10:574778. doi: 10.3389/fonc.2020.574778

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Tao, Hong, Tang, Lu, Zhao, Zhang, Ma and Xue

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Integrated and multiplexed IHC detection of immune landscape in ZS-HCC cohorts. (A). Seven-plex multispectral IHC images depict the immune landscape in HCC with tumor, peri-tumor, and margin invasion areas. (Iso) isotype-matched control antibody. Detailed single spectral image of seven-color panel, CD8 (red), CD68 (green), CD4 (white), CD56 (yellow), CD20 (cyan), CD14 (magenta), and DAPI (blue). Scale bars, 100 μm. (B). Comparison and distribution of the six-immune features between tumor and paired normal tissues in the training cohort (n = 258) and validation cohort (n = 178). *, **, *** denote P < 0.05, P < 0.01, and P < 0.001, respectively. NS denotes no significance (Mann-Whitney test). (C). Associations of the six-immune features in tumor areas with patients’ TNM stage in training cohort (n = 258).