Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 5;137:111363. doi: 10.1016/j.biopha.2021.111363

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Published by Elsevier Masson SAS.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

PMC Copyright notice

Fig. 2 — Ang 1–7 functions in several organs. ACE2 converts Ang II into Ang 1–7 which acts through its receptors (MasR). SARS-CoV-2 downregulates the expression of ACE2 and reduces the concentration of Ang 1–7 leading to progressive deterioration of physiological functions in patients with COVID-19 (Created in BioRender.com). ACE2: angiotensin converting enzyme2, Ang 1–9: Angiotensin 1–9, Ang 1–7: Angiotensin 1–7, MasR: mitochondrial assembly receptor, TGF-β: Transforming growth factor beta.