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. 2021 Feb 4;4(2):e2036512. doi: 10.1001/jamanetworkopen.2020.36512

Table 2. Prevalence of SUDDs by Geographic Region Among 15 637 Transgender and 56 911 Cisgender Adults, 2017a.

SUDD No. (%) Bivariate comparisonsb
Transgender (n = 15 637) Cisgender (n = 46 911) χ2 P value
Northeast
Total adults, No. 1963 5889
Nicotine 352 (17.9) 281 (4.8) 344.0 <.001
Alcohol 65 (3.3) 72 (1.2) 37.5 <.001
Cannabis 62 (3.2) 33 (0.6) 83.1 <.001
Cocaine 19 (1.0) 12 (0.2) 21.9 <.001
Opioid 32 (1.6) 32 (0.5) 21.5 <.001
Another drugc 49 (2.5) 36 (0.6) 48.9 <.001
South
Total adults, No. 6842 19 446
Nicotine 1103 (17.0) 1165 (6.0) 740.4 <.001
Alcohol 146 (2.3) 157 (0.8) 87.9 <.001
Cannabis 103 (1.6) 59 (0.3) 129.4 <.001
Cocained >24 (>0.4) >24 (>0.1) NA <.001
Opioid 89 (1.4) 92 (0.5) 56.8 <.001
Another drugc 110 (1.7) 79 (0.4) 111.9 <.001
Midwest
Total adults, No. 3760 11 280
Nicotine 673 (17.9) 695 (6.2) 469.9 <.001
Alcohol 118 (3.10) 112 (1.0) 86.2 <.001
Cannabis 94 (2.5) 49 (0.4) 127.8 <.001
Cocaine 27 (0.7) 12 (0.1) 40.8 <.001
Opioid 51 (1.4) 42 (0.4) 44.4 <.001
Another drugc 58 (1.5) 35 (0.3) 69.7 <.001
West
Total adults, No. 3432 10 296
Nicotine 466 (0.1) 410 (4.0) 396.8 <.001
Alcohol 72 (0.2) 97 (0.9) 28.3 <.001
Cannabis 62 (0.2) 45 (0.4) 62.4 <.001
Cocained <11 (<0.3) <11 (<0.1) NA .01
Opioid 33 (0.1) 41 (0.4) 15.2 <.001
Another drugc 48 (0.1) 33 (0.3) 51.0 <.001

Abbreviation: SUDD, substance use disorder diagnosis.

a

Hawaii and Alaska are included in the West according to the US Census. US territories (eg, Puerto Rico and Guam) are not included in US Census regions; thus the approximately 100 individuals without an assigned census region were included in the South.

b

Bivariate comparisons are between transgender and cisgender people in each region of the United States. Comparisons were also made in the frequency of each SUDD among transgender individuals across regions and among cisgender people across regions. Among transgender people, significant within group differences (P < .05) were observed for all SUDDs across regions with the exception of cocaine (P = .18). Among cisgender people, significant within group differences (P < .05) were observed for all SUDDs across regions with the exception of cocaine (P = .21) and opioid (P = .31) SUDDs.

c

Another drug SUDD includes hallucinogens, sedatives, stimulants, and the diagnosis of other SUD not otherwise specified.

d

Exact values are not reported to prevent back calculation and protect the confidentiality of individuals.