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. 2021 Feb 4;4(2):e2036512. doi: 10.1001/jamanetworkopen.2020.36512

Table 3. Substance Use Disorder Diagnoses by Gender Among Transfeminine Individuals, Transmasculine Individuals, Cisgender Male Individuals, and Cisgender Female Individuals in the US, 2017.

SUDD Transgender, No. (%) Bivariate comparison 1a Cisgender, No. (%) Bivariate comparison 2a
Transfeminine (n = 2079) Transmasculine (n = 4955) χ2 P value Male (n = 23 247) Female (n = 23 664) χ2 P value
Polysubstance 49 (2.4) 39 (0.8) 29.2 <.001 159 (0.7) 87 (0.4) 22.5 <.001
Nicotine 335 (16.1) 551 (11.1) 33.2 <.001 1272 (5.5) 1279 (5.4) 0.1 .75
Alcohol and drug 114 (5.5) 161 (3.2) 19.5 <.001 476 (2) 344 (1.5) 24.1 <.001
Alcohol 53 (2.5) 56 (1.1) 19.3 <.001 283 (1.2) 155 (0.7) 40.1 <.001
Drug 91 (4.4) 123 (2.5) 17.8 <.001 308 (1.3) 241 (1) 9.5 .002
Cannabis 48 (2.3) 42 (0.8) 24.8 <.001 114 (0.5) 72 (0.3) 10.3 .001
Cocaine 18 (0.9) <11 (0.3)b >14.8 <.001 35 (0.2) 24 (0.1) 2.3 .13
Opioid 23 (1.1) 51 (1.0) 0.1 .77 109 (0.5) 98 (0.4) 0.8 .37
Another drugc 31 (1.5) 40 (0.8) 6.9 .01 105 (0.45) 78 (0.3) 4.5 .03

Abbreviation: SUDD, substance use disorder diagnoses.

a

Using χ2 analyses, bivariate comparisons compare within-group differences in each SUDD category between transfeminine and transmasculine individuals (1) and cisgender male and female individuals (2).

b

To protect the confidentiality of individuals, exact values are not reported.

c

Another drug SUDD includes hallucinogens, sedatives, stimulants, and the diagnosis of other SUD not otherwise specified.