Table 1. Median HRs for Primary and Secondary End Points and Median Number of Events for Initial and Updated Reports Among the 41 Updated Trials.
| End point | Initial report | Updated report | P value of HRa | ||
|---|---|---|---|---|---|
| HR (range) | No. of events (range) | HR (range) | No. of events (range) | ||
| All trials (N = 41) | |||||
| Primary end point (n = 31) | 0.66 (0.22-1.20) | 160 (39-973) | 0.74 (0.32-1.19) | 239 (53-1244) | <.001 |
| Secondary end point (n = 26) | 0.72 (0.41-1.64) | 82 (20-518) | 0.74 (0.51-1.25) | 218 (33-1237) | .10 |
| Early disease (n = 27) | |||||
| Primary end point (n = 23) | 0.66 (0.22-1.20) | 136 (39-973) | 0.76 (0.42-1.19) | 215 (53-1244) | .001 |
| Secondary end point (n = 17) | 0.68 (0.41-1.15) | 73 (20-518) | 0.73 (0.51-1.12) | 274 (33-1237) | .02 |
| Advanced disease (n = 14) | |||||
| Primary end point (n = 8) | 0.66 (0.30-0.93) | 221 (121-394) | 0.66 (0.32-0.96) | 332 (184-779) | .04 |
| Secondary end point (n = 9) | 0.84 (0.67-1.64) | 103 (27-450) | 0.81 (0.61-1.25) | 178 (119-954) | .55 |
Abbreviation: HR, hazard ratio.
a
Calculated using the Wilcoxon signed rank test to compare HRs between initial and updated reports.