Table 4. Logistic Regression of Prognostic Factors of GG2 or Higher Cancer.
| Factor | TRUS Bx arm (n = 202) | MRI arm (n = 221) | ||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Age, y | 1.06 (1.01-1.10) | .01 | 1.07 (1.03-1.11) | .001 |
| Risk (high vs low risk) | 11.13 (3.57-34.71) | <.001 | 1.93 (0.80-4.67) | .15 |
| PSA (log-transform) | 5.40 (2.41-12.11) | <.001 | 2.76 (1.43-5.33) | .003 |
| BMI, U | 0.98 (0.91-1.05) | .53 | 1.05 (0.98-1.13) | .17 |
| Volume, U | 0.97 (0.95-0.99) | <.001 | 1.00 (0.99-1.00) | .41 |
| PSA density/0.1 U | 2.78 (1.88-4.10) | <.001 | 1.68 (1.25-2.27) | <.001 |
| Center | ||||
| LHSC | 1.77 (0.73-4.26) | .01 | 0.58 (0.24-1.41) | .35 |
| Sunnybrook | 0.50 (0.18-1.39) | 1.41 (0.60-3.30) | ||
| Jewish General | 2.86 (1.01-8.12) | 0.91 (0.34-2.47) | ||
| UHN | 0.75 (0.29-1.97) | 1.06 (0.45-2.50) | ||
| Vancouver | 1 [Reference] | 1 [Reference] | ||
| Family history | ||||
| Yes | 1 [Reference] | .59 | 1 [Reference] | .94 |
| No | 1.06 (0.57-2.00) | 1.12 (0.60-2.09) | ||
| Do not know | 1.87 (0.56-6.22) | 1.12 (0.29-4.25) | ||
| Palpable tumor | ||||
| Normal | 1 [Reference] | .01 | 1 [Reference] | .01 |
| Abnormal, cm | ||||
| ≤1.5 | 2.55 (1.27-5.12) | 3.04 (1.54-6.01) | ||
| >1.5 | 6.99 (1.30-37.49) | 1.74 (0.53-5.76) | ||
| Both lobes | 5.59 (0.49-63.38) | - | ||
| Prostate volume | ||||
| ≤20 | 7.67 (0.70-83.74) | .40 | Undefined | .32 |
| 21-35 | 1.38 (0.54-3.51) | 1.44 (0.64-3.24) | ||
| 36-50 | 1.20 (0.49-2.91) | 1.97 (0.96-4.06) | ||
| ≥51 | 1 [Reference] | 1 [Reference] | ||
| Multivariable analysis | ||||
| Risk (high vs low risk) | 4.98 (1.38-17.97) | .01 | NA | NA |
| Palpable tumor | ||||
| Normal | 1 [Reference] | .07 | 1 [Reference] | .001 |
| Abnormal, cm | ||||
| ≤1.5 | 2.51 (1.10-5.72) | 4.40 (1.96-9.89) | ||
| >1.5 | 6.05 (0.85-42.97) | 1.94 (0.51-7.45) | ||
| Both lobes | 2.36 (0.07-79.04) | |||
| PSA density/0.1 U | 2.24 (1.59-3.69) | <.001 | 2.16 (1.52-3.09) | <.001 |
| Age/y | NA | NA | 1.08 (1.03-1.13) | .001 |
| BMI | 1.15 (1.05-1.26) | .003 | ||
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); GG, International Society of Urological Pathology grade group; LHSC, London Health Sciences Centre; MRI, multiparametric magnetic resonance imaging; NA, not applicable; OR, odds ratio; PSA, prostate-specific antigen; TRUS Bx, systematic transrectal ultrasonography–guided biopsy; UHN, University Health Network.