Table 2. Summary of Evidence for Risk Factors for Ifosfamide-Related Encephalopathy.

	Risk factor	Risk factor status based on summary of the evidence
Patient characteristics	Age	Not a risk factor
	Gender	Insufficient data
	History of IRE	Insufficient data
	Multiple risk factors	Risk factor
	Performance status	Risk factor
	Bodyweight	Insufficient data
	Baseline cognitive impairment and delirium	Insufficient data
Physiologic	Renal insufficiency	Risk factor
	Hypoalbuminemia	Risk factor
	Hyperbilirubinemia	Insufficient data
	CBC abnormalities (platelet count, hemoglobin level, baseline and nadir WBC)	Insufficient data
	Transaminitis	Insufficient data
	Electrolyte abnormalities	Insufficient data
Treatment characteristics	Ifosfamide dose	Insufficient data
	Rate of infusion	Insufficient data
	Frequency of infusion	Insufficient data
Tumor burden	Pelvic disease	Insufficient data
	Brain metastasis	Insufficient data
Drug-drug interactions	Cisplatin exposure	Insufficient data
	Neurotoxic medications	Insufficient data
	Aprepitant	Not a risk factor

Note. IRE = ifosfamide-related encephalopathy; CBC = complete blood count; WBC = white blood cell.