Skip to main content
. 2021 Feb;191(2):335–352. doi: 10.1016/j.ajpath.2020.10.014

Figure 2.

Figure 2

Neoplastic HTLV-1 Tax+ cells are F4/80+, indicating a histiocytic malignancy. A: IHC analysis of a tumor along the ear pinna cartilage of a 6-month–old Tax+/IFN-γ−/− mouse for the macrophage-specific antigen F4/80. Neoplastic cells are consistently positive for F4/80. The round histiocytic tumor cells have more intense staining compared to the spindle-shaped tumor cells. B: Magnification (400x) with Aperio (Leica Biosystems) of F4/80 staining in Figure 2A. C: IHC analysis of HTLV-1 Tax reveals widespread cytoplasmic labelling with less-frequent nuclear staining in the neoplastic cells (100× magnification). D: Magnification (400x) with Aperio of HTLV-1 Tax staining in Figure 2C. Original magnification: ×100 (A and C).