Table 3.

Recommendations for the treatment of STIs.

	US guidelines46	European guidelines
Chlamydia trachomatis	Azithromycin 1 g PO once or Doxycycline 100 mg PO twice daily for 7 days	Azithromycin 1 g PO once or Doxycycline 100 mg PO twice daily for 7 days46
Neisseria gonorrhoeae	Ceftriaxone 250 mg IM once + Azithromycin 1 g PO once	Ceftriaxone 500 mg IM once + Azithromycin 2 g PO once49
HSV Primary infection	Acyclovir 400 mg PO three times daily for 7–10 days or Acyclovir 200 mg PO five times daily for 7–10 days or Valacyclovir 1 g PO two times daily for 7–10 days or Famciclovir 250 mg PO three times daily for 7–10 days	Acyclovir 400 mg PO three times daily for 5–10 days or Acyclovir 200 mg PO five times daily for 5–10 days or Valacyclovir 500 mg PO two times daily for 5–10 days or Famciclovir 250 mg PO three times daily for 5–10 days50
Trichomonas vaginalis	Metronidazole 2 g PO once or Tinidazole 2 g PO once	Metronidazole 400–500 mg PO twice daily for 5–7 days or Metronidazole 2 g PO once or Tinidazole 2 g PO once51
BV	Metronidazole 500 mg PO twice daily for 7 days or Metronidazole gel 0.75%, 5 g intravaginally for 5 days or Clindamycin cream 2% intravaginal gel once daily for 7 days	Metronidazole 400–500 mg PO twice daily for 5–7 days or Metronidazole gel 0.75%, 5 g intravaginally for 5 days or Clindamycin cream 2% intravaginal gel once daily for 7 days51

BV, bacterial vaginosis; HSV, herpes simplex virus; IM, intramuscular; PO, by mouth; STI, sexually transmitted infection; US, United States