Table 1.
Effusion b | Eosinophils c | Audiology d | |||||||
---|---|---|---|---|---|---|---|---|---|
Patient | Drug | No. of injections | Before | After | Before | After | Before | After | Side effects |
1 | Mepolizumab | 30 | Yes | No | 80 | Moderate, conductive | Mild-moderate, conductive | None | |
2 | Benralizumab | 8 | Yes | No | 600 | 0 | None | ||
3 | Mepolizumab | 27 | Yes | Yes | 1141 | 0 | None | ||
4 | Mepolizumab | 6 | No | No | 391 | Moderate SNHL | None | ||
5 | Mepolizumab | 21 | Yes | No | 454 | 100 | Moderate SNHL | Fatigue, myalgias | |
6 | Mepolizumab | 12 | Yes | No | 657 | Moderate, conductive | Mild, conductive | None | |
7 | Mepolizumab | Unclear | Yes | Yes | 370 | 0 | None | ||
8 | Benralizumab | 8 | Yes | No | 200 | 0 | Moderate, conductive | Moderate, conductive | None |
9 | Mepolizumab | 15 | No | No | 1137 | None |
Abbreviation: SNHL, sensorineural hearing loss.
Blank cells indicate not applicable.
Presence of middle ear effusion before and after starting anti-IL-5 therapy.
Absolute number of eosinophils present in serum before and after starting anti-IL-5 therapy.
Hearing loss based on audiologic results before and after starting anti-IL-5 therapy.