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. 2021 Feb 4;40:56. doi: 10.1186/s13046-021-01856-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — ACTL6A promotes cell proliferation and tumorigenicity via MYC signaling in TNBC cells. a Representative images (left) and quantification (right) of anchorage-independent growth colony formation for the indicated cell lines. Scale bars represent 200 μm. b Representative images (left) and quantification (right) of colony formation for the indicated cell lines. c MTT assays showed the cell proliferative capacity. d Flow cytometric analysis of TNBC cells with altered ACTL6A expression. e Vector/scramble, ACTL6A-overexpressed, ACTL6A-silenced or ACTL6A-shMYC SUM159PT cell lines were subcutaneously injected into mice (1 × 10⁶/injection, n = 6/group). The tumor volumes in each group are shown. f IHC of Ki-67 staining showed in the indicated xenografts. Scale bars represent 50 μm. Data represent the means ± S.D. of three independent experiments. Two-tailed Student’s t test was used. **P < 0.01, ***P < 0.001