Figure 7. AAV.Syne4 rescues behavioral response to sound in Syne4 ^−/− mice.

• A
  Schematic representation of cued fear conditioning experimental procedure.
• B, C
  Quantification of activity level and cumulative freezing duration at 12w during seconds 90–210 of day 2 in WT, Syne4 ^−/− mice, Syne4 ^−/− mice injected with AAV.Syne4, and Syne4 ^−/− mice injected with AAV.GFP, n = 14 for WT, n = 16 for Syne4 ^−/−, n = 9 for Syne4 ^−/− + AAV.Syne4, and n = 5 for Syne4 ^−/− + AAV.GFP. (C) Activity level. (B) Cumulative freezing duration. Statistical test was repeated‐measures ANOVA with Holm–Sidak correction for multiple comparisons, comparing the scores of each individual mouse before and after the appearance of the tone. Plots show mean ± SD. ***P < 0.001, ****P < 0.0001. ns = not significant.

Source data are available online for this figure.