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. 2020 Dec 28;13(2):e12710. doi: 10.15252/emmm.202012710

Figure 1. miR‐574‐5p and miR‐574‐3p expression is induced in human and mouse failing hearts.

Figure 1

  1. miRNA profiling identified miR‐574‐5p as the commonly upregulated miRNA in the hearts of aged mice, MI mice, and patients; and miR‐574‐3p is induced in exercised hearts and MI patients.
  2. Sequence and location of miR‐574 gene in the human genome.
  3. miR‐574‐5p and miR‐574‐3p were highly expressed in the explanted failing hearts from chronic HF patients (n = 17) versus donor non‐failing hearts (n = 6).
  4. miR‐574‐5p and miR‐574‐3p were induced in the hearts of mice with isoproterenol (ISO) infusion (4 weeks; n = 10–12).
  5. miR‐574‐5p and miR‐574‐3p were induced in the hearts of mice under transverse aortic constriction (TAC) surgery (4 weeks; n = 8–10).

Data information: Data were presented as mean ± SEM. P values were calculated by Mann–Whitney test (C) and unpaired two‐tailed Student t test (D, E).

Source data are available online for this figure.