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. 2020 Dec 28;13(2):e12710. doi: 10.15252/emmm.202012710

Figure 3. miR‐574 gene knockout augments TAC‐induced pathological cardiac remodeling.

Figure 3

  1. H&E staining of hearts from WT and miR‐574−/− mice 4 weeks after transverse aortic constriction (TAC) surgery.
  2. Ratio of HW/TL in WT and miR‐574−/− mice (n = 8 per group).
  3. WGA staining of hearts from WT and miR‐574−/− mice 4 weeks after TAC surgery (n ≥ 500 cells). Scale bar: 20 μm. In the violin plot, black line shows median value for the group and peach dashed lines represent two quartile lines in each group.
  4. Picrosirius red staining of hearts from WT and miR‐574−/− mice under TAC surgery (n = 8 per group). Scale bar: 1 mm.
  5. RT–qPCR of fetal cardiac genes in WT and miR‐574−/− mice with TAC surgery (n = 4 per group).
  6. Echocardiography measurement of cardiac functions of hearts from WT and miR‐574−/− mice 4 weeks post‐TAC (n = 8 per group). FS, fractional shortening.

Data information: Data were presented as mean ± SEM. P values were calculated by Kruskal–Wallis test with Dunn’s multiple comparisons test (C) or two‐way ANOVA with Tukey’s multiple comparisons test (B, D‐F).

Source data are available online for this figure.