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. 2020 Dec 28;13(2):e12710. doi: 10.15252/emmm.202012710

Figure 4. The therapeutic benefit of miR‐574‐5p/3p against cardiac pathological remodeling.

Figure 4

  1. The schematic of therapeutic treatment of the TAC model using miRNA mimics followed by phenotypic characterizations. HW/TL ratio is measured (n = 4–10 per group). Ctrl‐miR: negative control miRNA mimics.
  2. H&E and WGA staining of murine hearts in the therapeutic models. Scale bar: 1 mm for H&E and 50 μm for WGA. Cardiomyocyte surface area was quantified from WGA staining in the right panel. >120 CMs are quantified in each group. The black line shows medium value for the group and the dotted lines represent two quartile lines in each group.
  3. Picrosirius red staining of murine hearts in the therapeutic models. Scale bar: 1 mm. The fibrotic area was quantified in the right panel (n = 4–10 per group).
  4. Echocardiography analysis of the cardiac function of mice in the therapeutic models at the endpoint of 6 weeks post‐surgery (n = 4–10 per group).

Data information: Data were presented as mean ± SEM. P values were calculated by Kruskal–Wallis test with Dunn’s multiple comparisons test (A) or one‐way ANOVA with Tukey’s multiple comparisons test (B‐D).

Source data are available online for this figure.