. 2020 Dec 28;13(2):e12710. doi: 10.15252/emmm.202012710

Table 2.

Cardiac function of WT mice with miRNA treatment under TAC surgery

Parameter	Sham, Ctrl‐miR (n = 10)		TAC, Ctrl‐miR (n = 5)		TAC, miR‐574‐3p (n = 5)		TAC, miR‐574‐5p (n = 5)		TAC, miR‐574‐5p & 3p (n = 4)
Parameter	BL	6 week	BL	6 week	BL	6 week	BL	6 week	BL	6 week
HR (BPM)	565.04 ± 7.02	607.32 ± 7.96	571.05 ± 4.92	532.03 ± 9.32***	540.66 ± 16.30	553.35 ± 7.92	545.87 ± 14.16	563.16 ± 14.73	550.73 ± 11.49	549.72 ± 11.70
LVID,s (mm)	1.92 ± 0.039	2.00 ± 0.064	2.10 ± 0.112	3.90 ± 0.33***	2.28 ± 0.12	2.81 ± 0.107 ^††	2.24 ± 0.081	2.96 ± 0.298	1.88 ± 0.083	2.47 ± 0.166 ^†††
LVID,d (mm)	3.29 ± 0.097	3.51 ± 0.094	3.37 ± 0.121	4.59 ± 0.19***	3.42 ± 0.09	3.92 ± 0.076 ^†	3.52 ± 0.037	3.95 ± 0.220	3.25 ± 0.087	3.66 ± 0.163 ^†††
LVV,s (μL)	7.86 ± 0.330	8.99 ± 0.400	14.68 ± 1.68	66.21 ± 6.36***	18.08 ± 2.54	26.13 ± 4.08 ^††	17.16 ± 1.49	27.91 ± 3.39 ^††	11.14 ± 1.19	25.59 ± 6.46 ^†††
LVV,d (μL)	40.34 ± 1.63	43.58 ± 1.58	46.74 ± 3.58	100.38 ± 5.63***	48.44 ± 3.01	67.98 ± 5.96 ^†	51.59 ± 1.28	56.13 ± 8.45 ^†††	43.07 ± 2.59	62.48 ± 8.36 ^††
SV (μL)	36.83 ± 0.395	37.00 ± 0.447	32.06 ± 3.070	28.95 ± 5.27	30.36 ± 4.06	36.67 ± 2.404 ^†	34.43 ± 0.796	33.36 ± 2.249	31.66 ± 2.225	34.76 ± 3.898
EF (%)	80.52 ± 0.26	79.45 ± 0.31	68.49 ± 2.96	33.32 ± 3.25***	62.33 ± 5.71	61.88 ± 3.36 ^††	66.87 ± 2.30	54.63 ± 8.25 ^††	73.67 ± 2.09	62.06 ± 5.08 ^†††
FS (%)	47.93 ± 0.27	46.95 ± 0.29	48.10 ± 0.42	17.46 ± 1.91***	46.58 ± 0.31	34.27 ± 3.77 ^††	47.18 ± 0.50	30.44 ± 2.25 ^†	45.40 ± 0.39	35.05 ± 2.06 ^†††
CO (mL/min)	20.95 ± 0.370	21.39 ± 0.422	18.32 ± 1.756	15.49 ± 2.73*	16.41 ± 2.23	20.02 ± 1.908	18.81 ± 0.845	18.38 ± 1.221	17.51 ± 1.444	18.58 ± 1.905
LVM (mg)	54.98 ± 0.518	56.10 ± 1.336	60.26 ± 2.871	153.28 ± 20.31***	65.95 ± 2.35	96.17 ± 4.521 ^††	59.91 ± 4.109	110.83 ± 11.313 ^†	62.64 ± 2.777	99.49 ± 8.788 ^††
LVAWD,s (mm)	1.03 ± 0.02	1.09 ± 0.03	0.80 ± 0.02	1.14 ± 0.04	0.77 ± 0.01	0.95 ± 0.05 ^†	0.74 ± 0.04	0.97 ± 0.09 ^†	0.94 ± 0.05	0.92 ± 0.09
LVAWD,d (mm)	0.67 ± 0.01	0.71 ± 0.02	0.60 ± 0.03	1.22 ± 0.07**	0.66 ± 0.02	0.79 ± 0.04 ^††	0.59 ± 0.03	0.82 ± 0.07 ^†	0.72 ± 0.02	0.80 ± 0.06 ^†
LVPWD,s (mm)	0.88 ± 0.02	0.89 ± 0.02	0.83 ± 0.04	1.00 ± 0.07	0.77 ± 0.02	1.08 ± 0.06	0.72 ± 0.04	0.89 ± 0.08	0.92 ± 0.02	0.86 ± 0.07
LVPWD,d (mm)	0.55 ± 0.02	0.55 ± 0.01	0.60 ± 0.03	0.92 ± 0.05**	0.60 ± 0.02	0.81 ± 0.04 ^†	0.54 ± 0.03	0.80 ± 0.08 ^†	0.58 ± 0.09	0.77 ± 0.03 ^††
BW (g)	26.10 ± 0.25	28.49 ± 0.47	26.74 ± 0.11	25.26 ± 0.99*	27.30 ± 0.45	26.60 ± 1.05	26.90 ± 0.24	26.77 ± 0.93	26.70 ± 0.76	27.08 ± 0.36

Values are expressed as mean ± SEM.

P < 0.05, **P < 0.01, ***P < 0.001 for TAC, Ctrl‐miR vs. Sham, Ctrl‐miR.

^{^†}

P < 0.05, ^†† P < 0.01, ^††† P < 0.001 for TAC, Ctrl‐miR‐574‐3p/5p/3p & 5p vs. Sham, Ctrl‐miR.