Table 5.
Summary of studies that examined the distribution of control status, changes in clinical control and evaluated the predictive value of control
| Number of patients Study design |
Investigation objective | Study findings | |
|---|---|---|---|
| Baloira A et al. [9] (2016) |
481 patients Spanish cross-sectional multicenter study (primary care vs respiratory care) |
Distribution of control status | 36.8% of patients were controlled |
| Nibber A [9] et al. (2017) |
2788 patients Retrospective observational cohort study |
To validate the concept of control Distribution of control status |
4.5% of patients were controlled Time to first exacerbation was longer for controlled patients (p < 0.001) |
| Miravitlles M [10] et al. (2018) |
314 patients Multicenter prospective observational study |
To validate concept of control Distribution of control status |
32% of patients were controlled |
| Soler-Cataluña JJ [8] et al. (2018) |
265 patients Spanish multicenter prospective observational study |
To validate “modified” control criteria To evaluate predictive value of control |
61.5% of patients were controlled The time to the first combined event (emergency room visit, hospitalization, or death) was significantly greater in controlled patients (p < 0.001) |
| Barrecheguren [31] et al. (2020) |
2044 patients Multicenter double-blind SPARK study |
To validate the prospective value of control |
20% of patients were controlled The rate of exacerbations was lower in controlled patients (OR 0.56, p < 0.0001) and time to first exacerbation was significantly delayed |
| Miravitlles [32] et al. (2020) |
307 patients International, multicenter study |
To validate the concept of control in COPD |
65% of patients were controlled Time to first exacerbation was significantly delayed for controlled patients |
| Soler-Cataluña JJ [11] et al. (2020) |
354 patients Prospective multicenter observational study |
To compare changes in control over a 3-month period with changes in risk level and GOLD stage |
50.3% of patients were controlled Changes in control over a 3-month period was 29.3% |
| Miravitlles M [20] et al. (2020) |
267 patients International multicenter study Follow-up for 18 months |
To describe the changes in control status during follow-up (18 months) and the predictive value of control (6 months) | During 18 months of follow-up, 29.8% of patients remained controlled, 16% persistently uncontrolled and the remaining 53.7% changed control status during follow-up |