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. 2021 Feb 5;18:11. doi: 10.1186/s12970-021-00410-y

Table 7.

General characteristics of the studies included (Exercise characteristics as aerobic-based)

References Study Design Population characteristics Intervention Supplement situation Experimental design Physiological Results Performance results
[45] Randomized single-blind crossover 6 M: age 24 ± 4 y, height: 1.81 ± 0.10 m, and BM: 73.92 ± 11.46 kg)

4 mmol•kg− 1 BM of NaHCO3 or NaAc

Divided into two equal doses with 45 min interval

Last dose ingested 90 min before trial as NR once Cycling for 120 min at 119 ± 16 W (~ 50% VO2peak)

↑blood glucose and ↑Fat oxidation vs. NaAc (3.59 ± 0.45 and 0.11 ± 0.03 vs. 3,21 ± 0.43 and 0.07 ± 0.02)

=VO2, =VCO2, =RER, =BLa vs. NaAc

NR
[46] Randomized double-blind crossover 8 M: well-trained cyclists and triathletes, age: 31.4 ± 8.8 y, height: 184.6 ± 6.5 cm, BM: 74.1 ± 7.4 kg, 0.3 g•kg− 1 BM of NaHCO3 or 0.045 g•kg− 1 BM of NaCI (PLA) Ingested 90 min before the trial as tablets for 5 consecutive days Maintain constant-load cycling at ‘CP’ as long as possible ↑HCO3, ↑pH and ↑ABE vs. PLA (32.6 ± 2.7, 7.48 ± 0.02 and 8.3 ± 2.3 vs. 26 ± 1.1, 7.43 ± 0.02 and 2.0 ± 09), =Na+, =VO2, =VCO2, =RER and = HR vs. PLA

=CP vs. PLA

↑TTE (23.5%)

[30] Double-blind counterbalanced

11 trained cyclists,

age: 35.7 ± 7.1 y,

BM: 74.7 ± 10.0 kg,

height: 1.75 ± 0.10 m

0.15 g•kg− 1 BM of NH4CI or 0.03 g•kg− 1 BM of NaHCO3 or 0.15 g•kg− 1 BM of CaCO3 (PLA) Ingested 100 min before the trial in gelatin capsules once 4-km cycling ↑pH vs. PLA (7.3 ± 0.1 vs. 7.2 ± 0.07), =HCO3, =BE, =BLa, =VO2, =VCO2, =PO2, =PCO2 and = RPE vs. PLA =PO, =Anaerobic PO and = Aerobic PO vs. PLA
[47] Randomized double-blind crossover 21(16 M, 5F) well-trained cyclists: age: 24 ± 8 y, BMI: 21.3 ± 1.7 kg/m2 0.3 g·kg− 1 BM of NaHCO3 or 4 g NaCI (PLA) Ingested 2 h–1 h before the trial as NR once 30 min cycling at 95% IAT followed by exercising at 110% IAT until exhaustion

↑HCO3, ↑pH and ↑BE vs. PLA (27.6 ± 1.7, 7.45 ± 0.03 and 3.1 ± 1.6 vs. 21.4 ± 2, 7.38 ± 0.03 and − 2.6 ± 1.7), =BLa. =HR, =PCO2,

↓PO2 vs. PLA (83.4 ± 6.5 vs. 88 ± 6.2)

↑TTE vs. PLA (49.5 ± 11.5 min vs. 45.0 ± 9.5 min)
[48] Randomized single-blind crossover 8F elite hockey players, age: 23 ± 5 y, BM: 62.6 ± 8.4 kg, Height: 1.66 ± 0.05 m 0.3 g•kg− 1 BM of NaHCO3 or 0.02 g•kg− 1 BM of maltodextrin (PLA) Ingested 2/3 of NaHCO3 180 min before and 1/3 90 min before the trials in gelatin capsules once FSHT+ 2 LIST+FSHT+ 10 min recovery+ 2 LIST+FHST, about 75 min total ↑HCO3, ↑pH and ↑BE vs. PLA (21.7 ± 2.9, 7.41 ± 0.05 and − 2.3 ± 3.1 vs. 16.8 ± 1.6, 7.34 ± 0.06 and − 7.9 ± 1.8), =Bla, =glucose, =HR vs. PLA = Performance time and = Sprint time vs. PLA
[49] Randomized double-blind crossover

9 M, college tennis players

age 21.8 ± 2.4 y; height 1.73 ± 0.07 m

0.3 g•kg− 1 BM of NaHCO3 or 0.209 g•kg− 1 BM of NaCI (PLA) Ingested before 90 min of trial as NR for once Tennis simulated match, about 50 min ↑HCO3 and ↑BE vs. PLA (37.98 ± 3.15 and 11.36 ± 3.7 vs. 26.37 ± 3.5 and 0.12 ± 2.15), =pH, =BLa, =hematocrit, =HR and = RPE vs. PLA = Sport skill performance vs. PLA