Table 6.
Prognostic values of changes in body mass index within the first 2 years since diagnosis: multivariable Cox models
| Overall survival | Breast cancer-specific survival | Disease-free survival | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Events/persons | HR (95% CI)* | P | Events/persons | HR (95% CI)* | P | Events/persons | HR (95% CI)* | P | |
| Slope in the first 2 years after diagnosis | |||||||||
| Loss > 0.5 kg/m2/year | 113/680 | 1.69 (1.20–2.40) | 0.003 | 60/680 | 2.00 (1.20–3.34) | 0.008 | 129/659 | 1.54 (1.13–2.11) | 0.007 |
| Stable (≤ 0.5 kg/m2/year) | 57/804 | 1.0 (ref.) | 25/804 | 1.0 (ref.) | 72/786 | 1.0 (ref.) | |||
| Gain > 0.5 kg/m2/year | 59/775 | 1.10 (0.74–1.63) | 0.63 | 32/775 | 1.26 (0.72–2.22) | 0.42 | 86/757 | 1.16 (0.83–1.63) | 0.39 |
| Change from diagnosis to 18 months | |||||||||
| Loss > 5% | 65/356 | 1.60 (1.11–2.31) | 0.012 | 38/356 | 1.63 (0.99–2.69) | 0.053 | 65/346 | 1.33 (0.95–1.88) | 0.099 |
| Stable (≤ 5%) | 82/1127 | 1.0 (ref.) | 40/1127 | 1.0 (ref.) | 109/1106 | 1.0 (ref.) | |||
| Gain > 5% | 27/311 | 1.14 (0.72–1.81) | 0.58 | 13/311 | 0.95 (0.49–1.84) | 0.89 | 37/306 | 1.05 (0.70–1.57) | 0.81 |
*Adjusted for age, race, Carlson comorbidity index, tumor stage, histologic grade, molecular subtype, radiotherapy, hormonal therapy, and chemotherapy in delayed entry Cox models
Abbreviations: HR hazard ratio, CI confidence intervals