Tab. 5:

Minimal set of organ models enabling respective functions to establish MPS-based organismal homeostasis

No.	System	MPS-based organ model	Function
1	Circulatory	Cardiovascular	Blood transport
		Bone marrow	Hematopoiesis
2	Nervous	Brain	Generating and processing neuronal signals
		Ganglions and nerves	Innervation
3	Immune	Innate immunity	First line defense
4	Respiratory	Lung	Blood oxygenation
5	Digestive	Intestine	Absorption barrier, hosting microbiome
		Liver	Metabolism, protein production
6	Urinary	Kidney	Excretion
7	Endocrine	Pancreatic islets	Glucose regulation via insulin
8	Integumentary	Skin	Barrier
		Adipose	Storage, signaling
9	Musculoskeletal	Muscle	Metabolic homeostasis
10	Reproductive (optional)	E.g., testis	Generation of sperm