Table 3.
Common SNPs, Epigenetically Modified Genes, SNPs-diet Interactions and Metabolic Pathways Associated with Obesity and Obesity Traits.
| SNPs 12 | |||
|---|---|---|---|
| Gene | Phenotype | ||
| FTO | BMI, waist circumference, fat percentage, extreme obesity | ||
| MC4R | BMI, waist circumference, extreme obesity | ||
| MC3R, SLC6A14 | Obesity | ||
| BDNF, TMEM18 | BMI, extreme obesity | ||
| POMC, NEGR1, PCSK1, GNPDA2, MAP2K5, SEC16B | BMI | ||
| Epigenetically modified genes 26 | |||
| Gene | Phenotype | ||
| POMC, NPY, SLC6A4, MCHR1 | Overall obesity | ||
| FTO, LPL, IRS 1, TMEM18 | Fat distribution | ||
| PPARG | Percentage body fat | ||
| LEP | Overall obesity, fat distribution, BMI | ||
| SNPs-diet interactions 63 | |||
| Gene | Diet Interaction | Putative disease risk | |
| FTO | High Fat and High carbohydrate | Obesity | |
| LCT | Dairy products | ||
| PPARG, G1PR | High fat | ||
| TXN | Low vitamin E | Abdominal obesity | |
| MC4R | Western dietary pattern and high saturated fatty acids | Metabolic syndrome | |
| APOB | High fat | ||
| TCF7L2 | High saturated fatty acids | ||
| APOC3, APOA1 | Western dietary pattern | ||
| Deregulated metabolic signatures 64 | |||
| Metabolic pathway | Phenotype | ||
| Branched-chain amino-acid metabolism | Obesity and insulin resistance | ||
| Androgen synthesis | Childhood obesity | ||