TABLE 1.
GD2 concentrations in control samples and samples from children with neuroblastic tumors
C18 Lipoform of GD2 [nM] | ||||
---|---|---|---|---|
Group | N | Median | Range | Interquartile Range* |
Controls | 40 | 5.6 | <LLQ – 15.5 | <LLQ – 9.0 |
Ganglioneuroma | 10 | 4.1 | <LLQ – 9.4 | <LLQ – 5.2 |
Ganglioneuroblastoma – Intermixed | 12 | 6.4 | <LLQ – 15.3 | 4.1 – 9.0 |
Ganglioneuroblastoma – nodular | 16 | 39.1 | <LLQ – 258 | 8.4 – 136 |
GNB–n, stage 1–3 | 5 | 6.0 | <LLQ – 167 | |
GNB–n, stage 4 | 11 | 51.4 | 8.6 – 258 | 22.7 – 175 |
GNB–n, high risk | 13 | 47.7 | 4.5 – 258 | 13.0 – 140 |
Neuroblastoma (NBL) | 90 | 147 | 7.8 – 1060 | 45.4 – 300 |
NBL by stage | ||||
Stage 1–2 | 14 | 21.3 | 7.8 – 880 | 15.4 – 51.1 |
Stage 3 | 5 | 35.5 | 16.8 – 330 | |
Stage 4 | 69 | 188 | 16.1 – 1060 | 82.0 – 333 |
Stage 4S | 2 | 51.5 – 262 | ||
NBL by risk group (excluding 4S) | ||||
Low risk | 6 | 21.3 | 7.8 – 880 | |
Intermediate risk | 9 | 20.6 | 7.9 – 68.3 | 15.4 – 51.1 |
High risk | 73 | 167 | 16.1 – 1060 | 79.8 – 330 |
Relapsed neuroblastoma | 56 | 28.2 | 3.0 – 389 | 16.3 – 47.4 |
NBL post-consolidation | 11 | 8.2 | 3.0 – 21.1 | 5.8 – 11.2 |
Interquartile range derived for datasets with at least 7 samples