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. Author manuscript; available in PMC: 2021 Feb 5.
Published in final edited form as: Schizophr Res. 2014 Jan 8;152(2-3):373–380. doi: 10.1016/j.schres.2013.12.007

Figure 3. Promoter DNA methylation status of 5-HTT in SCZ versus control subjects.

Figure 3.

A. There was higher promoter DNA methylation in SCZ patients compared to the controls and first degree relatives of SCZ patients (SCZ FM) at site A. Notably, SCZ patients and drug naïve SCZ patients (DN SCZ) exhibit higher degree of DNA methylation. Drug use in SCZ patients (DU SCZ) reduced 5-HTT promoter DNA hypermethylation. B. Similar to site A, the 5-HTT promoter DNA methylation in SCZ was higher than controls at site B, particularly in drug naïve patients.