Figure 4. Promoter DNA methylation and expression and analysis for 5-HTT gene in post-mortem brains of patients with SCZ and BD versus the control subjects.
A: The Y axis indicates promoter DNA methylation of 5-HTT (site B) normalized with the PCR product of β-Actin promoter in SCZ and BD versus controls. B: The Y axis indicates relative expression of 5-HTT normalized with β-Actin expression. As shown, in SCZ the expression of 5-HTT is significantly less than controls as well as BD patients.