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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: FASEB J. 2021 Feb;35(2):e21335. doi: 10.1096/fj.202002257R

Fig. 1. ES-2 tumor induces muscle loss and impairs ribosome biogenesis resulting in a reduced translational capacity.

Fig. 1.

ES-2 tumor induced a significant loss of muscle mass (A) and rRNA (B). rDNA transcription in skeletal muscle of ES-2 tumor mice was significantly lower than control (C-D). The capacity for protein synthesis was compromised in tumor bearing mice, as reflected in lower puromycin incorporation into nascent peptides (E) and was consistent with translational repression as evidenced by a reduction in γ4E-BP1 relative to total 4E-BP1(F). Values are mean ± SD. *P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001 vs. control.