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. Author manuscript; available in PMC: 2022 Feb 1.
Published in final edited form as: FASEB J. 2021 Feb;35(2):e21335. doi: 10.1096/fj.202002257R

Fig. 5. ES-2 Tumor stimulates the expression of NUFIP1 mRNA and degradation of NUFIP1 protein.

Fig. 5.

Upregulation of NUFIP1 mRNA expression (A) and degradation of NUFIP1 protein (B) was observed in tumor bearing mice. NUFIP1 associated factor ZNHIT3 mRNA expression (C) showed no change. Autophagic flux, monitored via changes in LC3-II/I ratio, was higher in ES-2 tumor bearing mice and was driven by a significant reduction in LC3-I (D). Values are mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001 vs. control.