Table 1.

Inhaled exposures eliciting alveolar neutrophil accumulation through CD18-dependent vs. CD18-independent mechanisms

CD18-dependent stimuli		CD18-independent stimuli
E. coli LPS	[104, 105, 111]	S. pneumoniae	[104, 105]
P. aeruginosa	[105, 107]	CXCL1	[111]
E. coli	[279]	HCl (ipsilateral lung)	[104, 280]
HCl (contralateral lung)	[280]	S. aureus**	[279]
IgG immune complexes	[281]	Group B Streptococcus	[282]
		Hyperoxia	[283]
		IgG immune complexes	[281]

The cited reports measured alveolar neutrophilia in mice, rats, rabbits, or guinea pigs with either CD18 deletion (mice) or antibody neutralization of CD11 or CD18 β₂-integrin components. Partial effects on neutrophilia using the latter method may not decisively distinguish between technical (i.e., dosing) and biological causes

**Partially CD18-dependent