What are the local niche signals in the lung that sequentially program the tissue-compartmental localization and function of PMNs during pneumonia and its resolution?

Do pulmonary interstitial fibroblasts directly and/or indirectly regulate the transendothelial and transepithelial passage of PMNs in the lung?

Are there distinct subsets of PMNs that subserve destructive, antimicrobial, and repair roles in the lung?

How do intrapulmonary PMNs and the lung microbiota reciprocally interact during health and chronic lung disease?

Are there therapeutic strategies that can be leveraged to selectively intervene upon PMN traffic to the lung in isolation from other organs?

Are there molecular strategies that can be leveraged to selectively manipulate PMN number within the pulmonary intravascular, interstitial, and intra-alveolar compartments?

What is the relative importance of interstitial vs. intra-alveolar PMNs to host defense during pneumonia?

How does transepithelial traffic of PMNs impact intrapulmonary compartmentalization and clearance of pathogens during pneumonia?

What role does efferocytic clearance of apoptotic PMNs play in pathogen killing in the infected lung?