Table 2.
Characteristics at the time of kidney transplantation associated with graft loss or death
| Characteristic | Graft Loss from Any Cause | Graft Loss Censored for Patient Death | Death with a Functioning Graft | |||
|---|---|---|---|---|---|---|
| No. (%) with Outcome | Hazard Ratio (95% Confidence Interval) | No. (%) with Outcome | Hazard Ratio (95% Confidence Interval) | No. (%) with Outcome | Hazard Ratio (95% Confidence Interval) | |
| cPRA % | ||||||
| 0 | 217 (14) | Reference | 104 (7) | Reference | 113 (7) | Reference |
| 1–97 | 346 (18) | 1.04 (0.86 to 1.25) | 181 (10) | 1.07 (0.82 to 1.41) | 165 (9) | 1.01 (0.77 to 1.32) |
| 98–100 | 144 (25) | 1.39 (1.08 to 1.79) | 94 (16) | 1.78 (1.27 to 2.49) | 50 (9) | 0.92 (0.62 to 1.37) |
| Recipient age | ||||||
| 18–29 yr | 68 (17) | 1.45 (1.11 to 1.88) | 60 (15) | 2.35 (1.76 to 3.15) | 8 (2) | 0.36 (0.18 to 0.73) |
| 30–69 yr | 576 (17) | Reference | 303 (9) | Reference | 273 (8) | Reference |
| ≥70 yr | 63 (28) | 1.58 (1.21 to 2.06) | 16 (7) | 0.73 (0.44 to 1.22) | 47 (21) | 2.38 (1.72 to 3.29) |
| Male sex | 382 (18) | 1.13 (0.97 to 1.32) | 200 (9) | 1.14 (0.92 to 1.41) | 182 (8) | 1.11 (0.88 to 1.40) |
| Race | ||||||
| White | 584 (17) | Reference | 302 (9) | Reference | 282 (8) | Reference |
| Black | 102 (22) | 1.22 (0.99 to 1.51) | 65 (14) | 1.52 (1.16 to 1.99) | 37 (8) | 0.87 (0.88 to 1.40) |
| Other | 21 (10) | 0.65 (0.42 to 1.00) | 12 (6) | 0.75 (0.42 to 1.35) | 9 (4) | 0.59 (0.31 to 1.16) |
| Kidney failure due to diabetes | 233 (25) | 1.76 (1.48 to 2.09) | 99 (11) | 1.38 (1.08 to 1.77) | 124 (14) | 2.03 (1.60 to 2.57) |
| Insurance | ||||||
| Medicare | 447 (21) | Reference | 224 (10) | Reference | 223 (10) | Reference |
| Private | 178 (15) | 0.83 (0.70 to 0.99) | 99 (8) | 0.96 (0.76 to 1.23) | 79 (6) | 0.72 (0.55 to 0.94) |
| Other | 82 (12) | 0.76 (0.59 to 0.97) | 56 (8) | 1.06 (0.78 to 1.43) | 26 (4) | 0.47 (0.30 to 0.72) |
| Pretransplant dialysis (per yr) | 1.01 (1.00 to 1.02) | 1.00 (0.98 to 1.01) | 1.02 (1.01 to 1.04) | |||
| Donor characteristics | ||||||
| Living related | 105 (8) | Reference | 53 (4) | Reference | 52 (4) | Reference |
| Living unrelated | 6 (15) | 1.65 (0.72 to 3.77) | 6 (15) | 3.72 (1.58 to 8.77) | –a | –a |
| Deceased KDPI 0–20 | 153 (17) | 1.87 (1.43 to 2.45) | 77 (8) | 2.02 (1.38 to 2.96) | 76 (8) | 1.61 (1.10 to 2.36) |
| Deceased KDPI 21–50 | 222 (21) | 2.31 (1.79 to 2.98) | 119 (11) | 2.68 (1.87 to 3.82) | 103 (10) | 1.81 (1.26 to 2.36) |
| Deceased KDPI 51–85 | 194 (27) | 3.22 (2.49 to 4.16) | 112 (16) | 3.88 (2.72 to 5.54) | 82 (12) | 2.18 (1.50 to 3.17) |
| Deceased KDPI 86–100 | 27 (31) | 4.05 (2.61 to 6.29) | 12 (14) | 3.73 (1.95 to 7.14) | 15 (17) | 3.25 (1.79 to 5.90) |
| Induction therapy | ||||||
| Depleting | 498 (19) | Reference | 285 (11) | Reference | 213 (8) | Reference |
| Nondepleting | 128 (14) | 0.91 (0.74 to 1.12) | 55 (6) | 0.73 (0.54 to 0.99) | 73 (8) | 1.13 (0.85 to 1.50) |
| No induction | 76 (15) | 0.95 (0.64 to 1.22) | 38 (7) | 0.86 (0.61 to 1.22) | 38 (7) | 1.03 (0.72 to 1.47) |
Hazard ratios and 95% confidence intervals are shown. cPRA, calculated panel reactive antibody; KDPI, Kidney Donor Profile Index.
a
There were no cases of death with function among recipients of a living unrelated donor transplant.