TABLE IV.
Comparison between structures of Aβ(16–22) and Aβ(25–35) fragments and equivalent regions in Aβ(10–40).
| Aβ(16–22) | AWI (frag) | AWI (full) | Solution (frag) | Solution (full) |
|---|---|---|---|---|
| Rg/Å | 5.7 ± 0.4 | 6.1 ± 0.7 | 6.6 ± 0.6 | 7.5 ± 0.4 |
| Gmax/Å | 4.4 ± 0.5 | 4.9 ± 1.1 | 5.6 ± 0.9 | 7.0 ± 0.6 |
| Gmid/Å | 3.2 ± 0.3 | 3.2 ± 0.3 | 3.0 ± 0.4 | 2.5 ± 0.3 |
| Gmin/Å | 2.2 ± 0.3 | 2.1 ± 0.4 | 2.1 ± 0.3 | 1.9 ± 0.2 |
| NCα | 17 ± 2 | 16 ± 3 | 14 ± 1.5 | 12.4 ± 0.4 |
| NCγ | 4.6 ± 0.7 | 3.8 ± 0.6 | 4.0 ± 0.7 | 3.2 ± 0.7 |
| Nα−HB | 0.2 ± 0.3 | 1.0 ± 1.2 | 0.0 ± 0.1 | 0 ± 0 |
| N3−10 | 0.5 ± 0.4 | 0.8 ± 0.9 | 0.2 ± 0.2 | 0.05 ± 0.03 |
| DH | 6.8 ± 0.9 | 6.1 ± 2.4 | 8.2 ± 1.0 | 9.4 ± 0.4 |
| Aβ(25–35) | AWI (frag) | AWI (full) | Solution (frag) | Solution (full) |
| Rg/Å | 7.4 ± 1.1 | 7.4 ± 1.3 | 8.1 ± 1.2 | 8.6 ± 0.8 |
| Gmax/Å | 6.3 ± 1.3 | 6.3 ± 1.4 | 7.2 ± 1.5 | 7.3 ± 1.2 |
| Gmid/Å | 3.5 ± 0.5 | 3.2 ± 0.5 | 3.4 ± 0.5 | 3.8 ± 0.8 |
| Gmin/Å | 2.3 ± 0.3 | 2.3 ± 0.3 | 2.2 ± 0.3 | 2.2 ± 0.2 |
| NCα | 31 ± 5 | 32 ± 5 | 28 ± 4 | 26 ± 6 |
| NCγ | 4.5 ± 1.1 | 4.3 ± 1.3 | 3.7 ± 1.0 | 3.1 ± 0.6 |
| Nα−HB | 0.2 ± 0.5 | 1.1 ± 1.2 | 0.1 ± 0.1 | 0.05 ± 0.05 |
| N3−10 | 0.6 ± 0.5 | 1.1 ± 0.9 | 0.3 ± 0.3 | 0.3 ± 0.3 |
| DH | 12.2 ± 1.7 | 11.4 ± 2.3 | 13.5 ± 1.3 | 14.0 ± 1.0 |