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. Author manuscript; available in PMC: 2021 Feb 5.
Published in final edited form as: J Minim Invasive Gynecol. 2019 Nov 1;27(2):280–286. doi: 10.1016/j.jmig.2019.10.020

Fig. 2.

Fig. 2

Threshold model for how the additive effects of genetic risk factors, somatic mutations, and environmental risk factors in the population may combine to increase individual risk beyond the threshold for development of the disease. The large red arrows represent somatic mutations, blue arrows represent individual genetic risk factors, and gray arrows represent other environmental risk factors. Women with endometriosis will have a high burden of disease-causing risk factors made up from different combinations of genetic risk factors, somatic mutations in critical cell types, and environmental risk factors that predispose to disease (combinations of risk factors for individual women represented in circles on the right-hand side of the figure).