Figure 1.

14-3-3 proteins are highly abundant in human tissues with SARS-CoV-2 presence. Correlation of ACE2 expression levels (*) and SARS-CoV-2 reported presence (**) in various tissues of COVID19 patients based on the data from Trypsteen et al.,⁶ shown with abundances (indicated in ppm, part per million, i.e., one molecule of a given protein per 1 million of all proteins from a given tissue) of the seven human 14-3-3 isoforms, extracted from the PAXdb database.⁴⁰ Tissues are shown in the order corresponding to the SARS-CoV-2 presence, starting, at the top, from the highest virus presence.⁶ The shown relative scale of ACE2 expression is also taken from Trypsteen et al.⁶ The total abundance of the seven human 14-3-3 isoforms in a given tissue and the average abundance of an isoform in 12 selected tissues are also indicated. The latter values were used for ordering the data for 14-3-3 isoforms, left to right, from the highest average abundance (14-3-3ζ; 2423 ppm, or ~0.24%) to the lowest average abundance (14-3-3η; 575 ppm, or ~0.06%). Note that the average abundance of all seven 14-3-3 proteins in three tissues with the highest SARS-CoV-2 presence (oral cavity, gastrointestinal tract, lungs) reaches 1.21% of all proteins.