Table 2.

Comparison of kinetic parameters determined for p261N and hPolε at 20 °C

	p261Na	hPolε	p261N/hPolεb
k-1	0.021 s−1	0.0058 s−1	3.6
$K_{d(app)}^{DNA}$	79 nm	22 nm	3.6
kmax	252 s−1	411 s−1	0.6
$K_d^{dNTP,correct}$	23 μm	11 μm	2.1
kmax/$K_d^{dNTP,correct}$	11 μm−1 s−1	37 μm−1 s−1	0.3
kmax, mismatched	10−2 s−1	10- 3-100 s−1	10−2-101
kX, matched	0.17 s−1	0.015 s−1	11
kX, mismatchedc	2.6 s−1	0.45 s−1	5.8

^a References 19 and 21.

^b Calculated by dividing the kinetic parameter for p261N by the corresponding value measured for hPolε.

^c Averaged from measured k_X values for the M-1 and M-8 substrates.