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. 2020 Oct 13;295(50):17241–17250. doi: 10.1074/jbc.RA120.015757

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© 2020 Vasquez et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 6. — LukE DR1 is sufficient for Darc targeting in vivo. A, survival curve of Swiss Webster mice (females, 4–6 weeks old) challenged with IV purified toxin (n = 3–5 mice/group). B and C, survival curve of B6 WT (B) and Darc^−/− (C) mice (mixed males and females, 7–10 weeks old) injected with purified toxin via retro-orbital injection (n = 4–6 mice/group). LukS^E-DR1 indicates LukS-PV with the DR1 from LukE. SD indicates LukS-PV + LukD. The data are pooled from 2–3 independent experiments. **, p < 0.01; *, p < 0.05. A and B, Mantel–Cox test.