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. 2020 Oct 5;295(50):17138–17147. doi: 10.1074/jbc.RA120.014420

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© 2020 Oba et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc.

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Figure 4. — MARK4^ΔG316E317D increases tau levels and tau toxicity in a Ser-262/356–independent manner. A, MARK4^ΔG316E317D positively regulated tau levels in a Ser-262/356–independent manner. Western blots of fly heads expressing S2A tau alone or coexpressing S2A tau with either MARK4^wt (S2A tau+MARK4^wt) or MARK4^ΔG316E317D (S2A tau+MARK4^ΔG316E317D). Means ± S.D. (error bars), n = 4. n.s. (not significant), p > 0.05; ***p < 0.005 (one-way ANOVA and Tukey's post-hoc test). B, coexpression of S2A tau with MARK4^ΔG316E317D, but not with MARK4^wt, enhanced neurodegeneration. Shown are lamina of flies harboring expressing S2A tau (S2A tau), coexpressing S2A tau and MARK4^wt (S2A tau+MARK4^wt), or coexpressing S2A tau and MARK4^ΔG316E317D (S2A tau+MARK4^ΔG316E317D). Means ± S.E. (error bars); n = 5. n.s. (not significant), p > 0.05; ***p < 0.005 (one-way ANOVA and Tukey's post-hoc test).