Table 5.
Evaluation of PAK1 genetic interactions with respect to cell proliferation using pharmacological inhibitors
| Serial no. | Gene name | Inhibitor name | Proliferation assaya |
|
|---|---|---|---|---|
| GL26-PAK1-1 | GL26-PAK1-2 | |||
| 1 | DPP4 | Vildagliptin | + | ++ |
| 2 | KIF11 | Monastrol | − | − |
| 3 | METAP2 | Fumagillin | ++ | + |
| 4 | mTOR | Rapamycin | + | + |
| 5 | PKM2 | P-M2tide | ++ | + |
| 6 | TTK | MPS1-IN-1 | + | ++ |
a Genetic interaction with p value tested by cell proliferation assay in two independent clones of PAK1 stable transfectants (GL26-PAK1-1 and GL26-PAK1-2) (+, p < 0.05; ++, p < 0.01; −, not significant).