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. 2021 Feb;99(2):396–404. doi: 10.1016/j.kint.2020.09.028

Figure 2.

Figure 2

Plasma complement profile time course in Cfh–/–mice injected with IgG-FH1-5and anti-P-FH1-5. Plasma C3 (a,b), C5 (c,d), FB (e,f), and properdin (P; g,h) from experimental start until 27 days after single injection of IgG-FH1-5 (a,c,e,g; red triangles, n = 5) or anti-P-FH1-5 (b,d,f,h; urple triangles, n = 6). Controls included anti-P (green dots, n = 5) and an isotype-matched monoclonal antibody (IgG-control; blue dots, n = 5). Horizontal bars denote mean values, and whiskers denote SD. ∗P ≤ 0.05, ∗∗P ≤ 0.01, ∗∗∗P ≤ 0.001 versus pretreatment value and derived from 2-way analysis of variance with Bonferroni multiple comparisons test. FB, factor B; FH, factor H.