Figure 4.

Pretreatment with IgG-FH_1-5ameliorated renal injury during accelerated serum nephrotoxic nephritis in Cfh^–/–mice. (a) Schematic of the accelerated serum nephrotoxic nephritis protocol. Mice pre-immunized with sheep IgG received either IgG-FH_1-5 (treatment group, n = 8) or IgG-control (control group, n = 7) 24 hours before administration of the sheep nephrotoxic serum. (b) Renal function and histology 6 days after induction of accelerated serum nephrotoxic nephritis in mice treated with either IgG-FH_1-5 (treatment; red triangles, n = 8) or IgG-control (control; blue circles, n = 7). Horizontal bars denote median values, and whiskers denote interquartile range. ∗P ≤ 0.05, ∗∗P ≤ 0.01, ∗∗∗P ≤ 0.001 versus control and derived from Mann-Whitney test. FH, factor H; P, properdin.