. 2021 Jan 20;22(3):993. doi: 10.3390/ijms22030993

Table 1.

Morphology of microglia in the different amyotrophic lateral sclerosis (ALS) animal models based on genetic background, age, strain, collected tissue and microglial markers.

Model	Strain	Age	Tissue	Microglial Marker	Morphology	Reference
SOD1^G93A mouse	B6SJL-Tg	4–6 weeks	spinal cord	IBA1, CD11b	ND	[11]
SOD1^G93A mouse	B6SJL-Tg	9 and 14 weeks	spinal cord	IBA1	ND	[12]
SOD1^G93A mouse	B6SJL-Tg	10 and 14 weeks	spinal cord	IBA1	ND	[13]
SOD1^G93A mouse	B6SJL-Tg	12–14 weeks	spinal cord	IBA1, CD11b	Activated	[11]
SOD1^G93A mouse	B6SJL-Tg	14 and 20 weeks	spinal cord	IBA1	ND	[14]
SOD1^G93A mouse	B6SJL-Tg	16 and 19 weeks	medial reticular formation	IBA1, CD68	Amoeboid	[15]
SOD1^G93A mouse	B6SJL-Tg	16–17 weeks	spinal cord	CD11b	ND	[16]
SOD1^G93A mouse	B6SJL-Tg	17 weeks	retina, olfactory bulb	IBA1	Ramified	[17]
SOD1^G93A mouse	B6SJL-Tg	18 weeks	spinal cord	IBA1	ND	[18]
SOD1^G93A mouse	B6SJL-Tg	NM	spinal cord	IBA1	Activated	[19]
SOD1^G93A mouse	B6SJL-Tg	NM	spinal cord	CD11b	ND	[20]
SOD1^G93A mouse	B6.Cg-Tg	15 weeks	spinal cord	IBA1, CD40	Activated	[21]
SOD1^G93A mouse	B6.Cg-Tg	16 weeks	spinal cord	IBA1, CD36	Activated	[22]
SOD1^G93A mouse	B6.Cg-Tg	16 weeks	spinal cord	IBA1	ND	[23]
SOD1^G93A mouse	B6.Cg-Tg	17 weeks	spinal cord	IBA1, CD68	ND	[24]
SOD1^G93A mouse	B6.Cg-Tg	22 weeks	spinal cord	IBA1	ND	[25]
SOD1^G93A mouse	B6J-Tg	16 weeks	motor cortex, spinal cord	IBA1	ND	[26]
SOD1^G86R mouse	FVB/N	NM	spinal cord	IBA1	Activated	[27]
SOD1^G93A mouse	NM	15 weeks	spinal cord	IBA1, CD11b	ND	[28]
SOD1^G93A mouse	NM	14 weeks	spinal cord	IBA1	ND	[29]
SOD1^G93A mouse	NM	18 weeks	spinal cord	IBA1	Activated	[30]
Poly-GA mouse	C57BL/6N-Tg	3 weeks	hippocampus	IBA1	Amoeboid	[31]
Poly-GA-CFP mouse	C57BL/6N-Tg	26 weeks	spinal cord	IBA1, CD68	Phagocytic	[32]
Poly-GA mouse	C57BL/6J-Tg	28 weeks	spinal cord	IBA1	Activated	[33]
Poly-PR mouse	C57BL/6N-Tg	4 and 68 weeks	hippocampus	IBA1	Ramified	[31]
GFP-(GR)₁₀₀	C57BL/6J	6 weeks	brain	IBA1	ND	[34]
TDP-43^Q331K mouse	C57BL/6J-Tg	10 and 16 months	spinal cord	IBA1	Amoeboid	[35]
TDP-43^Q331K mouse	C57BL/6J-Tg	16 months	spinal cord	CD11b	Amoeboid	[35]
prpTDP-43^A315T UCHL1eGFP mouse	C57BL/6-Tg	3, 4 and 5 months	motor cortex	IBA1	Activated	[36]
TDP-43^A315T mouse	C57BL/6 x CBA-Tg	4.5 months	spinal cord	CD11b	ND	[37]
Wr mouse	C57BL/6J-wr	P20, P40 and P60	motor cortex, cerebellum	IBA1	ND	[38,39]
Wr mouse	NFR-wr	P28	spinal cord	CD11b	Ramified and clusters	[40]
Wr mouse	NFR-wr	P42	spinal cord	CD11b	Ramified and amoeboid	[41]
Wr mouse	NFR-wr	P60	spinal cord	IBA1	Highly reactive	[42]
Wr mouse	NFR-wr	P60	spinal cord	CD11b	ND	[42]
Wr mouse	NFR-wr	P63	spinal cord	CD11b	Activated	[40]
Wr mouse	NFR-wr	P70	spinal cord	CD11b	ND	[43]
Wr mouse	NFR-wr	P84	spinal cord	CD11b	ND	[44]
Wr mouse	NFR-wr	P90	dentate gyrus	IBA1	Amoeboid	[45]
Wr mouse	NFR-wr	P150	spinal cord	IBA1	ND	[46,47]
Wr mouse	NFR-wr	P150	spinal cord	IBA1	Highly ramified	[48]
Wr mouse	NFR-wr	P150	spinal cord	CD11b	ND	[46,47,48]

Wr: Wobbler; P (number): postnatal days; IBA1: ionized calcium binding adaptor molecule 1; CD: cluster of differentiation molecule; ND: not described; NM: not mentioned.