Table 3.

Microglial alterations in C9Orf72 mice based on the age, collected tissue and method.

Model.	Strain	Age	Tissue	Molecule	Variation	Method	Reference
Poly-GA mouse	C57BL/6	10 weeks	spinal cord	Cyr61	+	RNA-seq	[98]
Poly-GA mouse	C57BL/6J-Tg	28 weeks	spinal cord	Ccl4, Grn, Tyrobp	+	RNA-seq	[33]
Poly-GA mouse	C57BL/6N-Tg	7 weeks	brain	Mx1, Isg15, Oasl1/2, C3, C4b	+	RNA-seq	[31]
C9Orf72−/− mouse	C57BL/6J-Tg	N/A	spinal cord	Il-1β, Il-6	+	qRT-PCR	[89]

Variations are symbolized in terms of an increase (+) as compared to the age-matched wild type littermates. N/A: not applicable; Cyr61: cysteine rich angiogenic inducer 61; Ccl: C-C motif chemokine ligand; Grn: granulin; Tyrobp: TYRO protein tyrosine kinase binding protein; Mx1: interferon induced GTP binding protein Mx1; Isg15: interferon stimulated gene 15; Oasl1/2: 2′-5′-oligoadenylate synthase-like protein 1; C3: complement component 3; C4b: complement component 4b; IL: interleukin; RNA-seq: RNA sequencing; qRT-PCR: quantitative reverse transcription polymerase chain reaction.