. 2021 Jan 20;22(3):993. doi: 10.3390/ijms22030993

Table 4.

Microglial alterations in TDP-43 animal models based on the age, collected tissue and method.

Model.	Strain	Age	Tissue	Molecule	Variation	Method	Reference
TDP-43^Q331K mouse	C57BL/6J-Tg	10 and 16 months	spinal cord	C1qB, C4, C3, C5aR1, C1q	+	RT-PCR, IF	[35]
TDP-43^Q331K mouse	C57BL/6J-Tg	10 and 16 months	spinal cord	fB, CD59a, C5a	0	RT-PCR	[35]
TDP-43^Q331K mouse	C57BL/6J-Tg	10 and 16 months	spinal cord	CD55	−	RT-PCR	[35]
TDP-43^A315T mouse *	C57BL/6-Tg	N/A	spinal cord	Ym1, Arg1	+	WB	[104]
TDP-43^A315T mouse *	C57BL/6-Tg	N/A	spinal cord	Tnfα	0	WB	[104]
TDP-43^A315T mouse *	C57BL/6-Tg	N/A	spinal cord	p65 of NFκB	−	WB	[104]

Variations are symbolized in terms of increase (+), no change (0) and decrease (−) as compared to age-matched wild-type littermates. (* In this study, vehicle treated TDP-43^A315T mice were compared to ashwagandha-treated TDP-43^A315T mice.) N/A: not applicable; C1q: complement component 1q; C3: complement component 3; C4: complement component 4; C1qB: C1q beta polypeptide; C5a: complement component 5a; C5aR1: C5a receptor 1; fB: complement factor B; CD59a: complement regulator; CD55: complement regulator; Ym1: chitinase 3 like 1; Arg1: arginase 1; Tnfα: tumor necrosis factor alpha; NFκB: nuclear factor kappa B; RT-PCR: reverse transcription polymerase chain reaction, IF: immunofluorescent staining; WB: Western blotting.